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Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4) Size:100mg 1038/nature18621

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Description

1038/nature18621

Although tetramethylrhodamine (TMR) maleimides and iodoacetamides are popular thiol-reactive labeling reagents

molecular biology

CP-Tetrazine is a SNAP-tag substrate containg a methayltetrazine group for click chemistry applications

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4) Size:100mg 1038/nature18621SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX

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