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The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG4 moiety to enhance aqueous solubility
0]non-4-yne) is a strained cyclooctyne used in click chemistry for copper-free bioconjugation reactions
355 SMILES OCCCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Ex/Em = 553/577 nm
Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Size:10mg The conventional maleimidocaproyl (MC) unitSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl
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