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Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-MMAE ggfg Product Name Pomalidomide-5'-C3-amine HCl Synonyms

SKU 95939362540
4.2
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Description

Product Name Pomalidomide-5'-C3-amine HCl Synonyms CAS Number n/a Related CAS 2412056-37-0 (free base) Molecular Formula C16H19ClN4O4 Molecular Weight 366

489 SMILES OCCNC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

68 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCC#C)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

It binds with high affinity to DDB1-CRBN

Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-MMAE ggfg Product Name Pomalidomide-5'-C3-amine HCl SynonymsSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly

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