Thalidomide-O-C3-OH aldehyde 88 SMILES: NCCCCC(NS(=O)(=O)C1=CC=C(C(=C1)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S([O-])(=O)=O)C(O)=O

88 SMILES: NCCCCC(NS(=O)(=O)C1=CC=C(C(=C1)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S([O-])(=O)=O)C(O)=O

459 SMILES [N-]=[N+]=NCCCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

97 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCCCN=[N]#N)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)N(CCCS([O-])(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

439 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCCOCCOCC#C Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Thalidomide-O-C3-OH aldehyde 88 SMILES: NCCCCC(NS(=O)(=O)C1=CC=C(C(=C1)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S([O-])(=O)=O)C(O)=ODegrader building block for targeted protein degradation. Contains an E3 ligase ligand with a linker and a function group, which can be conjugated to target protein ligands through straightforward chemical reactions. Product Name Thalidomide O C3 OH Synonyms Thalidomide 4' O C3 OH CAS Number 2416740 42 4 Related CAS Molecular Formula C16H16N2O6 Molecular Weight 332. 312 SMILES OCCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping