Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-Exatecan peg3 respectively)

respectively)

Product Name Pomalidomide-5'-C3-amine HCl Synonyms CAS Number n/a Related CAS 2412056-37-0 (free base) Molecular Formula C16H19ClN4O4 Molecular Weight 366

Product Name Phthalimidinoglutarimide-C3-O-PEG1-OH Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG1-OH CAS Number n/a Related CAS Molecular Formula C18H22N2O5 Molecular Weight 346

318 SMILES OCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-Exatecan peg3 respectively)SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I