DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:1mg 512 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC#C)CCN(CC(O)=O)CC1 Purity (HPLC)

512 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC#C)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name BC-TCO Synonyms CLIP-TCO CAS Number Related CAS Molecular Formula C21H26N4O3 Molecular Weight 382

334 SMILES O=C(CCC#C)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

406 SMILES: O=C(CCC(=O)N1CC2=CC=CC=C2C#CC2=C1C=CC=C2)ON1C(=O)CCC1=O Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:1mg 512 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC#C)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further