Thalidomide-5'-piperazine-C2-piperazine HCl e3 Product Name DOTA-tris(t-Bu)ester-PEG6-propargyl Synonyms CAS

Product Name DOTA-tris(t-Bu)ester-PEG6-propargyl Synonyms CAS Number n/a Related CAS Molecular Formula C43H79N5O13 Molecular Weight 874

GW5074 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT)

87 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

31 SMILES FC(F)(F)C1=CC(SC2=C(Cl)C=CC=C2Cl)=C(C(=O)N2CC3=CC=CC(C#N)=C3C2)C(=O)N1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Thalidomide-5'-piperazine-C2-piperazine HCl e3 Product Name DOTA-tris(t-Bu)ester-PEG6-propargyl Synonyms CASProtein degrader building block. Contains cereblon ligand Thalidomid and 5' substituted heterocyclic linker. Product Name Thalidomide 5' piperazine C2 piperazine HCl Synonyms CAS Number n a Related CAS Molecular Formula C23H33Cl3N6O4 Molecular Weight 563. 91 SMILES Cl. Cl. Cl. O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(=CC=C12)N1CCN(CCN2CCNCC2)CC1 Purity (HPLC) 95% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For