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NVP-DKY709 acts as a molular glue that promotes degardation of IKZF2 for the treatment of cancers
Compared with regular HaloTag Ligand
Product Name BODIPY FL VH032 Synonyms CAS Number 2770675-66-4 Related CAS Molecular Formula C46H62BF2N7O9S Molecular Weight 937
84 SMILES Cl
Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-PNP tamra NVP-DKY709 acts as a molularSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating
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