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and a C-terminal 7-Amino-4-methylcoumarin (AMC) moiety
308 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C(OCCC#C)C=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
By combining P1 and P18
The payload is monomethyl auristatin E (MMAE)
Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE gly and a C-terminal 7-Amino-4-methylcoumarin (AMC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
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