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TCO (trans-cyclooctene) is a strained alkene used in click chemistry for bioorthogonal reactions like iEDDA (inverse electron-demand Diels-Alder)
Westermann
Product Name Pomalidomide-PEG5-C2-azide Synonyms Pomalidomide-4'-PEG5-C2-azide CAS Number 2624181-61-7 Related CAS Molecular Formula C25H34N6O9 Molecular Weight 562
resulting in decreased CDK12 substrate phosphorylation
Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-PNP Size:100mg TCO (trans-cyclooctene) is a strainedSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload
