Azide-Dap(m-PEG4)-Val-Cit-PAB piperazine Nat Rev Drug Discov 2021

Nat Rev Drug Discov 2021

074 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

59 Purity (HPLC) >= 95% Physical Appearance Orange Solid Optical Properties Abs/Em Maxima: 503/509 nm Solubility DMSO Shipping Conditions Shipped on gel packs Storage Conditions Store at -20°C and protected from light Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1

Azide-Dap(m-PEG4)-Val-Cit-PAB piperazine Nat Rev Drug Discov 2021SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine