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MC-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg 362 SMILES OCCCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC)

SKU 69617705082
4.3
USD495.00 USD535.00

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Description

362 SMILES OCCCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Thalidomide-O-C3-acid Synonyms Thalidomide-4'-O-C3-acid CAS Number 2169266-64-0 Related CAS Molecular Formula C17H16N2O7 Molecular Weight 360

NRX-103095 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome

Product Name BG-DOTA-tris(t-Bu) Synonyms SNAP-DOTA-tris(t-Bu) CAS Number n/a Related CAS Molecular Formula C41H64N10O8 Molecular Weight 825

MC-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg 362 SMILES OCCCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker

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