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demonstrating a DC50 of 19 nM against GFP-HaloTag7 fusion proteins
which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of CLIP-fusion proteins
Trametiglue acts as molecular glue
Product Name Lenalidomide-PEG5-C2-amine HCl Synonyms Lenalidomide-4'-PEG5-C2-amine HCl CAS Number 2138440-77-2 Related CAS Molecular Formula C25H39ClN4O8 Molecular Weight 559
Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg demonstrating a DC50 of 19SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage
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