Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg 616 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

616 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

168 SMILES [2H]C([2H])([2H])OC1=CC=C(C=C1)C#N Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-PEG3-C2-azide Synonyms CAS Number 1428146-79-5 Related CAS Molecular Formula C24H44N8O10 Molecular Weight 604

Product Name Phthalimidinoglutarimide-C5-OH Synonyms Phthalimidinoglutarimide-4'-C5-OH CAS Number 2138441-34-4 Related CAS Molecular Formula C18H22N2O4 Molecular Weight 330

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg 616 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC