DBCO-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium 6-isomer Synonyms: 6-Carboxytetramethylrhodamine

6-isomer Synonyms: 6-Carboxytetramethylrhodamine

Product Name Pomalidomide-5'-C1-acid Synonyms CAS Number 2412056-27-8 Related CAS Molecular Formula C15H13N3O6 Molecular Weight 331

Product Name: 5-TAMRA Synonyms: 5-Carboxytetramethylrhodamine CAS Number: 91809-66-4 Molecular Formula: C25H22N2O5 Molecular Weight: 430

Product Name Phthalimidinoglutarimide-C4-Br Synonyms Phthalimidinoglutarimide-4'-C4-Br CAS Number n/a Related CAS Molecular Formula C17H19BrN2O3 Molecular Weight 379

DBCO-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium 6-isomer Synonyms: 6-CarboxytetramethylrhodamineSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU