Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE payload SHP099 is a highly potent

SHP099 is a highly potent (IC50 = 0

Product Name Thalidomide-O-C3-acid Synonyms Thalidomide-4'-O-C3-acid CAS Number 2169266-64-0 Related CAS Molecular Formula C17H16N2O7 Molecular Weight 360

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1

986 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE payload SHP099 is a highly potentSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Azide Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further