DBCO-Dap(m-PEG4)-Val-Cit-PAB-PNP cyclopropene Product Name Thalidomide-5'-propargyl-PEG1-OH Synonyms CAS

Product Name Thalidomide-5'-propargyl-PEG1-OH Synonyms CAS Number n/a Related CAS Molecular Formula C18H16N2O6 Molecular Weight 356

CDCF) can passively diffuse into cells and is colorless and nonfluorescent until the acetate groups are cleaved by intracellular esterases to yield the fluorescent fluorophore

67 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

DBCO-Dap(m-PEG4)-Val-Cit-PAB-PNP cyclopropene Product Name Thalidomide-5'-propargyl-PEG1-OH Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,