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347 SMILES OC(=O)CCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
BODIPY (boron-dipyrromethene
002 Purity (HPLC) >= 95% Solubility DMSO
which binds to DCAF1 with a Kd by SPR and IC50 by TR-FRET of <50 nM
Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan Size:25mg 347 SMILES OC(=O)CCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by
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