Propargyl-Acetyl-Val-Ala-PAB(m-PEG8)-MMAE Size:25mg Contains an E3 ligase ligand

Contains an E3 ligase ligand substituted with piperazine

48 SMILES Cl

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG2 moiety to enhance aqueous solubility

Propargyl-Acetyl-Val-Ala-PAB(m-PEG8)-MMAE Size:25mg Contains an E3 ligase ligandSOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing