Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP dbco-propionyl 94 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC)

94 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

The BODIPY FL thalidomide-mediated Cereblon Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP dbco-propionyl 94 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase