Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan pab Product Name 1-bromo-2-(methoxy-d3)benzene Synonyms 1-bromo-2-(²H3)methoxybenzene

Product Name 1-bromo-2-(methoxy-d3)benzene Synonyms 1-bromo-2-(²H3)methoxybenzene CAS Number 892397-56-7 Related CAS Molecular Formula C7H7BrO Molecular Weight 190

Signal Transduction and Targeted Therapy

78 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

546 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C(OCCOCCOCCOCCOCCOCC#C)C=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan pab Product Name 1-bromo-2-(methoxy-d3)benzene Synonyms 1-bromo-2-(²H3)methoxybenzeneSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is