MC-Val-Ala-PAB(m-PEG8)-Exatecan ca Product Name Phthalimidinoglutarimide-propargyl-O-PEG1-C2-amine HCl Synonyms

Product Name Phthalimidinoglutarimide-propargyl-O-PEG1-C2-amine HCl Synonyms Phthalimidinoglutarimide-4'-propargyl-O-PEG1-C2-amine HCl CAS Number 2138440-68-1 Related CAS Molecular Formula C20H24ClN3O5 Molecular Weight 421

92 SMILES Cl

Product Name Thalidomide-O-PEG5-C2-Cl Synonyms Thalidomide-4'-O-PEG5-C2-Cl CAS Number n/a Related CAS Molecular Formula C25H33ClN2O10 Molecular Weight 556

Product Name DOTA-pentyne Synonyms CAS Number n/a Related CAS Molecular Formula C21H35N5O7 Molecular Weight 469

MC-Val-Ala-PAB(m-PEG8)-Exatecan ca Product Name Phthalimidinoglutarimide-propargyl-O-PEG1-C2-amine HCl SynonymsSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,