Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:5mg 93 SMILES: [O-]S(=O)(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S(=O)(=O)NCCOCCOCCOCC#C Purity (HPLC):

93 SMILES: [O-]S(=O)(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S(=O)(=O)NCCOCCOCCOCC#C Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name DOTA-tris(t-Bu)ester-PEG2-C2-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C41H71N7O12 Molecular Weight 854

Product Name Mal-Propionyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB Synonyms CAS Number Related CAS Molecular Formula C42H56N8O14 Molecular Weight 896

HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:5mg 93 SMILES: [O-]S(=O)(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S(=O)(=O)NCCOCCOCCOCC#C Purity (HPLC):SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,