DBCO-Hexanoyl-Val-Cit-PAB(m-PEG8) Size:25mg Structural basis for the action

Structural basis for the action of the drug trametinib at KSR-bound MEK

16 SMILES CC1(C)CCC(CN2CCN(CC2)C2=CC=C(C(O)=O)C(CC3=CN=C4NCCC4=C3)=C2)=C(C1)C1=CC=C(Cl)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

74 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

054 SMILES [2H]C([2H])([2H])OC1=CC=CC=C1Br Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Hexanoyl-Val-Cit-PAB(m-PEG8) Size:25mg Structural basis for the actionSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned through selection