Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg 193 Purity (HPLC) >= 95%

193 Purity (HPLC) >= 95% Solubility DMSO

88 SMILES: NCCCCC(NS(=O)(=O)C1=CC=C(C(=C1)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S([O-])(=O)=O)C(O)=O

Product Name Thalidomide-O-PEG4-C2-amine HCl Synonyms Thalidomide-4'-O-PEG4-C2-amine HCl CAS Number 2820929-03-9 Related CAS 2401832-00-4 (free base) Molecular Formula C23H32ClN3O9 Molecular Weight 529

S)-AHPC hydrochloride Synonyms VH 032 CAS Number 1448189-80-7 Related CAS 1448297-52-6 (free base) Molecular Formula C22H32Cl2N4O3S Molecular Weight 503

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg 193 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I