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Scientific Reports
CC-92480 promotes rapid and extensive degradation of Aiolos/Ikaros than s lenalidomide and pomalidomide
Product Name: 5(6)-TAMRA PEG3 azide Synonyms: 5/6-Carboxytetramethylrhodamine-PEG3-Azide CAS Number: 604810-60-8 Molecular Formula: C33H38N6O7 Molecular Weight: 630
this product contains a PEG4 linker instead of PEG2
Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4) dbco-propionyl Scientific ReportsSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker
