Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan dmea Product Name Lenalidomide-CO-C3-OH Synonyms Lenalidomide-4'-CO-C3-OH

Product Name Lenalidomide-CO-C3-OH Synonyms Lenalidomide-4'-CO-C3-OH CAS Number n/a Related CAS Molecular Formula C17H19N3O5 Molecular Weight 345

CC(C)(C)C(=O)OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=C(C=C13)C(=O)NCCOCCOCCOCC#C)C1=CC=C(OC(=O)C(C)(C)C)C=C1O2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

82 SMILES ClC1=CC=C(NC(=O)CSC2=NN=C3C(NC4=CC=CC=C34)=N2)N=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

279 SMILES BrCCCCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 90% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan dmea Product Name Lenalidomide-CO-C3-OH Synonyms Lenalidomide-4'-CO-C3-OHSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent