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We then performed enrichment analysis to identify the molecular function of the identified protein complex, which participated in the process of regulation of response to stimulus and immune system. Similar to previous over-representation analysis, the gene products are mainly found in extracellular space and endoplasmic reticulum. The identification of this module as the most significant protein complex in the network and subsequent functional annotation unveil a shared upregulated immune mechanism behind CD and SI-NET that is particularly mediated by IL-6 in the extracellular space and the endoplasmic reticulum
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